Drug targeting looks inward
نویسندگان
چکیده
منابع مشابه
Organelle targeting: third level of drug targeting
Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the ther...
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1982). It is not clear how the rate of entry into lysosomes themselves is affected, but it may be retarded. The situation is even more obscure in the case of entry into lysosomes by autophagy. There are some indications of abnormalities in endogenous protein breakdown, and in perhaps of the lysosomal component thereof, in I-cell disease (Cockle & Dean, 1984). Similarly, Sameshima et al. (1981) ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1999
ISSN: 1087-0156,1546-1696
DOI: 10.1038/7850